The Palace is the seventh and last progression area of the game. It contains 3 stages: 7-1, 7-2, and 7-3. Its third area is different from any other in that it only houses the boss and always has the same layout instead of being procedurally generated. The first two stages consist of medium sized rooms connected by short corridors, while 7-3 is always a long corridor leading to the boss.
- The boss theme for The Nuclear Throne is "Nuclear Throne".